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Long-term anti-TNFalpha therapy for ankylosing spondylitis in two patients with chronic HBV infection.

Sakellariou GT, Chatzigiannis I

Department of Rheumatology, St. Paul's Hospital, 161 Ethnikis Andistaseos Str, 55134, Thessaloniki, Greece. sakelgr@otenet.gr

Anti-TNFalpha therapy for rheumatic diseases appears to be safe in patients with chronic hepatitis C. However, the administration of anti-TNFalpha agents without initiation of prophylactic antiviral therapy (lamivudine 100 mg/day) in patients with chronic HBV infection results in exacerbation of liver disease. In this report, we describe our experience of long-term anti-TNFalpha therapy for ankylosing spondylitis in two inactive HBsAg carriers without preemptive antiviral treatment.

Published 30 April 2007 in Clin Rheumatol, 26(6): 950-2.
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