Flat Feet Research Today is a free monthly online journal that collates and summarizes the latest research about Flat Feet, including details on flatfoot, fallen arches, children, treatment, arthrodesis.

Ankylosing spondylitis: new treatment modalities.

Brandt J, Marzo-Ortega H, Emery P

Rheumatologische Praxisgemeinschaft, Berlin, Germany.

Ankylosing spondylitis (AS) is a chronic and progressive inflammatory arthropathy that affects young adults. It is associated with increased morbidity and mortality, and can have a devastating effect on quality of life. Conventional therapeutic regimes have traditionally been insufficient to control symptoms and signs of disease, and have failed to halt disease progression. However, the outlook of AS has changed with the advent of biological agents that block pivotal inflammatory cytokines, such as tumour necrosis factor-alpha. Ongoing research has proven these agents to be efficacious and safe in the short and medium term. Further, longer-term trials are awaited to address the issue of whether these therapies are true disease modifiers in AS.

Published 16 June 2006 in Best Pract Res Clin Rheumatol, 20(3): 559-70.
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